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Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress.

Nature neuroscience · 2025 · 28(6): 1174-1184

Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged …

PMID 40456907 DOI ↗